It includes 5 (five) groups of female mice as which are K1 (CMC), K2 (CMC+MSG), P1 (MSG+0.4 mg Temulawak extract), P2 (MSG+0.8 MG Temulawak extract), P3 (MSG+1.2 mg Temulawak extract). However, this research adopts true experimental post-test only control group design. The amount of antioxidant found Temulawak extract is categorized as active and applicable as natural antioxidant source. Temulawak extract contains antioxidant, properties for as much as 87.01 ppm, according to Rosidi research’s result, analyzing the Temulawak’s potentials. Therefore, the extract of Temulawak is promoted to be the attempt to resolve the issue for its antioxidant properties. Hence, any malfunctions resided in the human’s hypothalamus can possibly put endocrine gland into troubles, such as reproduction hormones which affect the workings of gonad. These two hormones, however, are essentials for the development of gonad and during the cycles of oogenesis. Yet, it is known that hypothalamus produces Gonadotropin Releasing Hormone which is able to stimulate the secretion of Gonadotropin Follicle Stimulating Hormon and Luteinizing Hormone from the anterior pituitary gland. Monosodium Glutamat activates an axis ablation in arcuate nucleus hypothalamus which happens to possibly initiate malfunctions in Hipothalamic Pituitary Adrenal axis.
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